Abstract
The neural specific monoclonal antibody A2B5 was found to interact with GQ1c but not with Gq1b, nor did it interact with other glycolipids such as GM1, GD1a, GD1b, GT1a, GT1b and GA1. Since GQ1c is enriched in embryonic chicken brains but not in adult chicken brains, this antibody should be useful as a tool in assessing the role of GQ1c in neuronal maturation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal / immunology*
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Antibody Specificity
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Brain / immunology
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Brain / metabolism
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Cattle
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Chick Embryo
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Gangliosides / biosynthesis
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Gangliosides / immunology*
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Humans
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Retina / immunology
Substances
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Antibodies, Monoclonal
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Gangliosides
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tetrasialoganglioside GQ1c