Opioid antagonists inhibit the growth of metastatic murine neuroblastoma

Cancer Lett. 1983 Nov;21(1):89-94. doi: 10.1016/0304-3835(83)90087-3.

Abstract

Naltrexone (NTX), an opiate antagonist, had an inhibitory effect on the growth of S20 Y neuroblastoma (NB) in A/Jax mice. Daily injections of 0.1 mg/kg NTX resulted in a 69% tumor take, 70% delay in time prior to tumor appearance, and a 60% increase in median survival time. Inoculation of NB in control mice resulted in 100% tumor take within 15 days. The pattern and incidence of metastases of NTX and control mice were similar. These results show that NTX has antineoplastic activity, and suggests a role for the endogenous opioid system in neuro-oncogenic events.

MeSH terms

  • Animals
  • Cell Line
  • Male
  • Mice
  • Naloxone / analogs & derivatives*
  • Naltrexone / therapeutic use*
  • Neoplasm Transplantation
  • Neuroblastoma / drug therapy*
  • Neuroblastoma / pathology
  • Probability
  • Time Factors

Substances

  • Naloxone
  • Naltrexone