The nephrotic syndrome in IgA glomerulonephritis: response to corticosteroid therapy

Clin Nephrol. 1983 Oct;20(4):172-6.

Abstract

The nephrotic syndrome was observed in eight out of 170 patients with IgA glomerulonephritis (5%). Three patients had mild glomerular alterations, all of them were normotensive, had normal renal function and responded to treatment with corticosteroids. In five patients moderate to marked mesangial changes associated with segmental sclerosing or proliferative lesions were seen. These patients were hypertensive and four of them had renal insufficiency. Three were treated with corticosteroids without response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use*
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Female
  • Glomerulonephritis / drug therapy*
  • Glomerulonephritis / immunology
  • Glomerulonephritis / pathology
  • Humans
  • Immunoglobulin A / immunology
  • Kidney Glomerulus / pathology
  • Kidney Glomerulus / ultrastructure
  • Male
  • Methylprednisolone / therapeutic use
  • Microscopy, Electron
  • Middle Aged
  • Nephrotic Syndrome / drug therapy*
  • Prednisolone / therapeutic use

Substances

  • Adrenal Cortex Hormones
  • Immunoglobulin A
  • Prednisolone
  • Methylprednisolone