Plasma membrane: can its structure and function be modulated by dietary fat?

Comp Biochem Physiol B. 1983;76(2):335-9. doi: 10.1016/0305-0491(83)90079-2.


Compositional analysis of plasma membranes from rats fed nutritionally adequate diets different in fatty acid composition establishes that fundamentally different dietary fat intake results in alteration in structural lipid composition of plasma membranes in brain, liver and the intestinal mucosa. Dietary differences in fatty acid intake altered the fatty acyl tail composition of plasma membrane phospholipids in brain, liver and intestinal mucosa. Diet altered the phospholipid profile observed in brain synaptosomal and liver plasma membrane. Feeding high vs low polyunsaturated to saturated fat diets for 7 days altered the fatty acid composition of phosphatidylcholine, phosphatidylethanolamine, sphingomyelin and monoglucosylceramide isolated from plasma membrane of the intestinal mucosa.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / metabolism
  • Cell Membrane / drug effects
  • Cell Membrane / metabolism*
  • Dietary Fats / pharmacology*
  • Fatty Acids / metabolism
  • Fatty Acids / pharmacology*
  • Intestinal Mucosa / metabolism
  • Liver / metabolism
  • Male
  • Membrane Lipids / metabolism*
  • Phospholipids / metabolism
  • Rats
  • Rats, Inbred Strains


  • Dietary Fats
  • Fatty Acids
  • Membrane Lipids
  • Phospholipids