Prolactin lowering effect of amphetamine in normoprolactinemic subjects and in physiological and pathological hyperprolactinemia

Horm Metab Res. 1983 Sep;15(9):439-43. doi: 10.1055/s-2007-1018749.

Abstract

The effect on plasma prolactin (PRL) of d-amphetamine (Amph) was studied in normo- and hyperprolactinemic subjects. In normoprolactinemic women Amph failed to lower plasma PRL levels when infused intravenously over 1 h at the dose of 7.5 mg, but induced at the dose of 15.0 mg a modest inhibition of plasma PRL (maximum PRL inhibition 20 +/- 4.5% at 45 min). Likewise, in puerperal women Amph at the dose of 7.5 mg did not decrease significantly plasma PRL levels but it was active in this respect (maximum inhibition 37 +/- 10% at 120 min) at the dose of 15.0 mg. In subjects with presumptive evidence of a PRL-secreting adenoma, Amph at either the 7.5 mg or the 15.0 mg dose failed to alter baseline PRL levels. These results indicate that Amph is a poor PRL suppressor in either normo- or hyperprolactinemic subjects. It is proposed that this may be due to the drug's ability to effect release of dopamine mainly from a non-granular pool of the amine.

MeSH terms

  • Adenoma / metabolism
  • Adult
  • Depression, Chemical
  • Dextroamphetamine / administration & dosage
  • Dextroamphetamine / pharmacology*
  • Dopamine / metabolism
  • Female
  • Humans
  • Infusions, Parenteral
  • Pituitary Neoplasms / metabolism
  • Postpartum Period
  • Pregnancy
  • Prolactin / blood*
  • Prolactin / metabolism

Substances

  • Prolactin
  • Dextroamphetamine
  • Dopamine