Abstract
Tetrahydrofuranyl and tetrahydropyranyl derivatives of neospiramycin I at 3 and/or 4' position were synthesized. In vitro and in vivo activities of these derivatives were correlated with the position and configuration of acetal groups. The most effective derivative, 3-a, 4'-a-di-O-tetrahydrofuranylneospiramycin I was comparable to spiramycin I.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Bacteria / drug effects
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Indicators and Reagents
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Leucomycins / chemical synthesis*
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Leucomycins / toxicity
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Microbial Sensitivity Tests
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Optical Rotation
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Spiramycin* / analogs & derivatives*
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Indicators and Reagents
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Leucomycins
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neospiramycin I
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Spiramycin