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, 306 (5943), 551-7

Cholera Toxin Genes: Nucleotide Sequence, Deletion Analysis and Vaccine Development

Cholera Toxin Genes: Nucleotide Sequence, Deletion Analysis and Vaccine Development

J J Mekalanos et al. Nature.

Abstract

Nucleotide sequence and deletion analysis have been used to identify the regulatory and coding sequences comprising the cholera toxin operon (ctx). Incorporation of defined in vitro-generated ctx deletion mutations into Vibrio cholerae by in vivo genetic recombination produced strains which have practical value in cholera vaccine development.

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