Ventricular enlargement in teenage patients with schizophrenia spectrum disorder

Am J Psychiatry. 1983 Dec;140(12):1592-5. doi: 10.1176/ajp.140.12.1592.


Recent research has demonstrated statistically significant differences between the ventricular-brain ratios (VBRs) of schizophrenic patients and control subjects. In this study the VBRs of teenage schizophrenic/schizophreniform patients (N = 15) and borderline patients (N = 8) were measured and compared with those of controls of similar ages (N = 18). The schizophrenic group had significantly larger ventricles than the other two groups (p less than .0001). These findings support the hypothesis of previous investigators that ventricular enlargement is present early in the course of schizophrenia.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Age Factors
  • Borderline Personality Disorder / diagnosis
  • Brain / diagnostic imaging*
  • Female
  • Humans
  • Hydrocephalus / diagnostic imaging*
  • Male
  • Psychotic Disorders / diagnosis*
  • Schizophrenia / diagnosis*
  • Time Factors
  • Tomography, X-Ray Computed