Linkage analysis and family classification under heterogeneity

Ann Hum Genet. 1983 Oct;47(4):311-20. doi: 10.1111/j.1469-1809.1983.tb01001.x.


Heterogeneity of the recombination fraction may or may not involve a mixture of two groups of elements. For the mixture situation (families with or without linkage between two gene loci), Morton's homogeneity test is compared with another test (Admixture test) with respect to significance level, power, parameter estimation and classification of families. The Admixture test is shown generally to have superior properties in this situation.

Publication types

  • Comparative Study

MeSH terms

  • Chromosome Mapping
  • Family Characteristics
  • Family*
  • Genetic Linkage*
  • Humans
  • Methods
  • Recombination, Genetic*