Comparison of the kinetics and utilisation of D(-)-and L(+)-sodium lactate in normal man

Ann Nutr Metab. 1983;27(6):481-7. doi: 10.1159/000176723.

Abstract

After infusion of sodium D(-)L(+)-lactate in healthy man the clearance of the D(-)-isomer from blood was 70% of that of the L(+)-isomer. Utilisation of L(+)-lactate may have been inhibited by the presence of the D(-)-isomer. The changes in blood pyruvate concentration and ketone body ratio were compatible with mitochondrial oxidation of D(-)-lactate to pyruvate. After infusion of a D(-)L(+)-lactate racemic mixture, the renal excretion of the D(-)-isomer was much greater than that of the L(+)-isomer, although peak blood concentrations of the L(+) were higher than those of the D(-)-isomer. After infusion of sodium L(+)-lactate, the renal excretion of D(-)-lactate increased 7 times, although no D(-)-lactate could be detected in the blood or in the sodium L(+)-lactate infused.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3-Hydroxybutyric Acid
  • Acetoacetates / blood
  • Adult
  • Alanine / blood
  • Female
  • Humans
  • Hydroxybutyrates / blood
  • Kinetics
  • Lactates / blood
  • Lactates / metabolism*
  • Lactates / urine
  • Lactic Acid
  • Male
  • Pyruvates / blood
  • Pyruvic Acid
  • Stereoisomerism

Substances

  • Acetoacetates
  • Hydroxybutyrates
  • Lactates
  • Pyruvates
  • Lactic Acid
  • acetoacetic acid
  • Pyruvic Acid
  • Alanine
  • 3-Hydroxybutyric Acid