Parkinson's disease affects differently Met5- and Leu5-enkephalin in the human brain

Brain Res. 1983 Dec 5;280(2):379-82. doi: 10.1016/0006-8993(83)90071-9.


When measured in post-mortem human control brains, the ratio of Met5-enkephalin levels to those of Leu5-enkephalin varied from 1 to 13 in the 11 areas examined. In parkinsonian brains a significant reduction in the levels of both peptides was found in the pallidum and putamen whereas only Met5-enkephalin levels were decreased in the substantia nigra and ventral tegmental area. Therefore, Met5-enkephalin and Leu5-enkephalin may be located (at least partly) in different neuronal populations in the human brain.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / pathology
  • Brain Chemistry*
  • Enkephalin, Leucine / analysis*
  • Enkephalin, Methionine / analysis*
  • Humans
  • Parkinson Disease / metabolism*
  • Parkinson Disease / pathology
  • Reference Values
  • Tissue Distribution


  • Enkephalin, Methionine
  • Enkephalin, Leucine