Intercellular karyotypic similarity in near-diploid cell lines of human tumor origins

Cancer Genet Cytogenet. 1983 Dec;10(4):351-62. doi: 10.1016/0165-4608(83)90092-4.


Intercellular karyotypic compositions were studied in seven near-diploid cultured cell populations (including six cell lines) of human colorectal and fibrosarcoma origins. Within each population, 50-88% of cells had the same cell-line-specific karyotype. In five of these seven populations, coexisting minor cell types could readily be identified, implicating the frequent occurrence of mosaicism in transformed cell lines. Nearly 90% of these cell types showed a single chromosome loss or gain from the modal cell karyotype. Parameters that may assist in the evaluation of karyotypic diversity of a transformed cell line are discussed briefly.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma / genetics*
  • Cell Line*
  • Chromosome Banding
  • Colonic Neoplasms / genetics*
  • Fibrosarcoma / genetics
  • Humans
  • Karyotyping