Studies on chemotherapy of parasitic helminths (XVIII). Mechanism of spastically paralyzing action of pyrantel in Angiostrongylus cantonensis

Experientia. 1983 Dec 15;39(12):1383-5. doi: 10.1007/BF01990115.

Abstract

Pyrantel tartrate caused spastic paralysis through stimulating nicotinic cholinoceptors in Angiostrongylus cantonensis.

MeSH terms

  • Angiostrongylus / physiology*
  • Animals
  • Female
  • Metastrongyloidea / physiology*
  • Movement / drug effects
  • Nematode Infections / drug therapy
  • Pyrantel / analogs & derivatives*
  • Pyrantel Tartrate / pharmacology*
  • Pyrantel Tartrate / therapeutic use
  • Rats
  • Receptors, Nicotinic / drug effects
  • Tubocurarine / pharmacology
  • gamma-Aminobutyric Acid / pharmacology

Substances

  • Receptors, Nicotinic
  • Pyrantel
  • gamma-Aminobutyric Acid
  • Pyrantel Tartrate
  • Tubocurarine