Diabetic gastroparesis: treatment with domperidone--a double-blind, placebo-controlled trial

Digestion. 1983;27(4):214-7. doi: 10.1159/000198955.


6 patients with severe symptomatic diabetic gastroparesis were studied in a placebo-controlled randomized manner to establish if intravenous domperidone accelerates the delayed gastric emptying of a semisolid homogenized meal. Domperidone, 10 mg intravenously, shortened the gastric emptying half-time in all of the 6 patients significantly, but not in the healthy control subjects. These results suggest that intravenous domperidone may be potentially beneficial to diabetic gastroparesis patients by improving delayed gastric emptying.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Diabetes Mellitus, Type 1 / complications*
  • Diabetes Mellitus, Type 1 / physiopathology
  • Domperidone / therapeutic use*
  • Double-Blind Method
  • Female
  • Gastric Emptying / drug effects*
  • Humans
  • Male
  • Middle Aged


  • Domperidone