Influence of vitamin C status on the urinary excretion of catecholamines in stress

Hum Nutr Clin Nutr. 1983 Dec;37(6):405-11.


A group of volunteers on a low intake of ascorbate was compared with another group supplemented with 3 g of ascorbate daily with regard to urinary excretion of catecholamines and cortisol after exposure to a specified stressor. The low-dose group excreted less adrenaline than the high-dose group, whereas excretion of dopamine, noradrenaline and cortisol was largely unchanged. This effect may indicate another role in vivo of vitamin C in the biosynthesis of catecholamines besides that of a cofactor to a specific enzyme. The results suggest a role for ascorbate in an adequate response to stress.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Ascorbic Acid / administration & dosage*
  • Ascorbic Acid / physiology
  • Catecholamines / metabolism
  • Catecholamines / urine*
  • Color Perception Tests
  • Dopamine / urine
  • Dose-Response Relationship, Drug
  • Epinephrine / urine
  • Humans
  • Hydrocortisone / urine*
  • Male
  • Norepinephrine / urine
  • Stress, Psychological / urine*


  • Catecholamines
  • Ascorbic Acid
  • Dopamine
  • Hydrocortisone
  • Norepinephrine
  • Epinephrine