Acetylcholine excites identified septo-hippocampal neurons in the rat

Neurosci Lett. 1983 Dec 23;43(1):43-7. doi: 10.1016/0304-3940(83)90126-x.


Neurons of the medial septum-nucleus of the diagonal band of Broca (vertical limb) area were identified as septo-hippocampal neurons by antidromic electrical activation in anesthetized rats. A large majority of these presumably cholinergic neurons could be excited by the iontophoretic application of acetylcholine or cholinergic agonists such as carbachol. The acetylcholine-induced excitations were readily antagonized by atropine. These results suggest that cholinergic neurons can be excited by their own transmitter, i.e. acetylcholine.

MeSH terms

  • Acetylcholine / pharmacology*
  • Animals
  • Carbachol / pharmacology
  • Hippocampus / drug effects
  • Hippocampus / physiology*
  • Male
  • Neurons / drug effects
  • Neurons / physiology*
  • Rats
  • Rats, Inbred Strains


  • Carbachol
  • Acetylcholine