Assessment of disease activity in ulcerative colitis using indium-111-labelled leukocyte faecal excretion

Scand J Gastroenterol. 1983 Oct;18(7):907-12. doi: 10.3109/00365528309182114.


A new method of assessing disease activity in ulcerative colitis has been developed utilizing indium-111-labelled granulocytes. Faecal 111In excretion after intravenous administration of labelled granulocytes ranged from 1.1% to 45% of the injected dose in patients with ulcerative colitis, showing significant differences between mild, moderate, and severely active groups. There was a significant correlation between faecal 111In excretion and a clinical index based on the Crohn's disease activity index (r = 0.79, p less than 0.001) and the erythrocyte sedimentation rate (r = 0.73, p less than 0.001). Quantitative faecal 111In-labelled granulocyte excretion is an objective and specific method of assessing disease activity in ulcerative colitis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Blood Sedimentation
  • Colitis, Ulcerative / diagnosis*
  • Feces / analysis*
  • Female
  • Granulocytes / analysis*
  • Humans
  • Indium*
  • Leukocytes / analysis
  • Male
  • Middle Aged
  • Prospective Studies
  • Radioisotopes*


  • Radioisotopes
  • Indium