Chloroquine in long-term treatment of rheumatoid arthritis

Clin Rheumatol. 1983 Dec;2(4):393-9. doi: 10.1007/BF02041561.

Abstract

The effect of long-term (18-70 months) chloroquine treatment 250 mg daily, in rheumatoid arthritis (RA) was studied in 20 patients. Sedimentation rates were significantly reduced, as compared to a reference group of 10 RA patients on no treatment of disease modifying anti-rheumatic drugs. Radiographical progression of the disease was low in the majority of chloroquine-treated patients but not significantly different from the finding in the patients of the reference group. Rapid radiographical progression during 2-3 years was, however, observed in 5 patients despite chloroquine treatment.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / blood
  • Arthritis, Rheumatoid / diagnostic imaging
  • Arthritis, Rheumatoid / drug therapy*
  • Arthrography
  • Blood Sedimentation
  • Chloroquine / therapeutic use*
  • Female
  • Hemoglobin A / analysis
  • Humans
  • Male
  • Middle Aged
  • Time Factors

Substances

  • Chloroquine
  • Hemoglobin A