Brain metastases from colon cancer

J Neurooncol. 1983;1(3):203-9. doi: 10.1007/BF00165604.

Abstract

Between 1977 and 1980 we evaluated 40 patients who developed brain metastases from colon cancer (4% of total patients with colon cancer). The brain metastasis was discovered in only one patient prior to cancer diagnosis; all others had known colon cancer for 2 to 48 months (median 24.5 months) prior to neurologic presentation. The colon tumor was left-sided in 32; 32 had regional lymph node metastases at neurological presentation; 37 patients had extensive systemic metastasis as well as the brain lesion. Median survival from onset of therapy for brain metastasis was 9 weeks in 32 radiation therapy (RT) treated patients (range, 2-57 weeks), 37 weeks in 7 surgically resected patients (2-84 weeks), and 4 weeks (3.5 weeks) in 2 chemotherapy patients. Follow-up demonstrated recurrent tumor (median 4 months). The prognosis for patients with brain metastasis in colon cancer is poor, regardless of therapy.

MeSH terms

  • Adenocarcinoma / diagnosis
  • Adenocarcinoma / secondary*
  • Adenocarcinoma / therapy
  • Adult
  • Aged
  • Brain / diagnostic imaging
  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / secondary*
  • Brain Neoplasms / therapy
  • Colonic Neoplasms / diagnosis*
  • Colonic Neoplasms / therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Tomography, X-Ray Computed