1,25-dihydroxyvitamin D3 Inhibits Proliferation of Human Promyelocytic Leukaemia (HL60) Cells and Induces Monocyte-Macrophage Differentiation in HL60 and Normal Human Bone Marrow Cells

Leuk Res. 1983;7(1):51-5. doi: 10.1016/0145-2126(83)90057-7.

Abstract

1,25-dihydroxyvitamin D3 induces monocyte-macrophage differentiation and inhibits proliferation of cells from the human promyelocytic leukaemia cell line HL60. Similarly human bone marrow progenitor cells differentiate preferentially along the monocyte-macrophage pathway when incubated in the presence of 1,25-dihydroxyvitamin D3. We suggest that the inhibition of growth which occurs after addition of the vitamin to HL60 might be paralleled in vivo by inhibition of proliferation of leukaemic cells; also we speculate that the vitamin may be involved in the control of both monocyte-macrophage and osteoclast production in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Marrow / drug effects
  • Cell Differentiation / drug effects
  • Cell Division / drug effects
  • Cell Line
  • Cells, Cultured
  • Dihydroxycholecalciferols / pharmacology*
  • Humans
  • Leukemia, Experimental / pathology*
  • Macrophages / drug effects
  • Monocytes / drug effects

Substances

  • Dihydroxycholecalciferols
  • 1 alpha,24-dihydroxyvitamin D3