Antibacterial effect of cyanoacrylate glue

Arch Ophthalmol. 1983 Jun;101(6):958-60. doi: 10.1001/archopht.1983.01040010958022.


Enbucrilate (butyl-2-cyanoacrylate; Histoacryl [West Germany], no comparable US product) is a tissue adhesive used in the management of corneal perforations that may have a therapeutic value in suppressing selective pathogens isolated, from corneal infections. In three patients with confirmed corneal infections, varying degrees of inhibition were observed. Bacteriostatic activity was most pronounced against gram-positive microorganisms, and no activity was observed against gram-negative organisms. It appears that this chemical adhesive provided an ancillary means of promoting healing of corneal perforations.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Corneal Diseases / drug therapy*
  • Enbucrilate / therapeutic use*
  • Female
  • Humans
  • Staphylococcal Infections / drug therapy*
  • Streptococcal Infections / drug therapy


  • Enbucrilate