A relationship between ascorbic acid and threonic acid in guinea-pigs

Food Chem Toxicol. 1983 Aug;21(4):449-52. doi: 10.1016/0278-6915(83)90101-1.


Threonic acid is a major breakdown product of ascorbic acid used as a food additive. When administered orally to guinea-pigs (100 mg/kg body weight) for periods of 4 or 28 days, it produced a significant fall in the ascorbic acid concentration of certain organs but was without effect on other physiological and biochemical characteristics. The lifespan of scorbutic guinea-pigs was significantly reduced by dietary threonic acid (100 mg/kg body weight). The results indicate that threonic acid may modify the metabolism of ascorbic acid in guinea-pigs.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Ascorbic Acid / administration & dosage
  • Ascorbic Acid / metabolism*
  • Ascorbic Acid Deficiency / metabolism
  • Butyrates*
  • Drug Interactions
  • Food Additives / metabolism*
  • Guinea Pigs
  • Hydroxybutyrates / administration & dosage
  • Hydroxybutyrates / metabolism*
  • Longevity / drug effects
  • Male
  • Organ Size / drug effects
  • Time Factors
  • Tissue Distribution


  • Butyrates
  • Food Additives
  • Hydroxybutyrates
  • threonic acid
  • Ascorbic Acid