Cervical choriocarcinoma associated with an intrauterine contraceptive device: a case report

Am J Obstet Gynecol. 1983 Oct 1;147(3):343-4. doi: 10.1016/0002-9378(83)91127-4.


PIP: Choriocarcinoma most commonly occurs within the uterine corpus. Just as placental implantation rarely occurs in the cervix, choriocarcinoma of the cervix is unusual. A case is presented of a 35-year old white woman, para 1-0-0-1 who had an uneventful term pregnancy 1 year prior to admission. She used an IUD and reported regular menses until 3 months prior to admission when she noted irregular bleeding. At initial examination a serum pregnancy test was positive, indicating a mass thought to be a cervical leiomyoma and bilateral cystic ovaries. Pathologic interpretation of an endocervical curettage was choriocarcinoma. At that point a hysterectomy was performed; there were no further complications and the patient subsequently received 3 additional courses of methotrexate. Cervical choriocarcionoma may develop from cervical metastases from a primary tumor in the corpus which later spontaneously regresses, malignant transformation of a cervical pregnancy, or transport of chorionic cells from a preceding pregnancy that undergo malignant transformations after a dormant period. In the nulliparous patient the conservation of reproductive function should be considered if possible.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Choriocarcinoma / etiology*
  • Choriocarcinoma / pathology
  • Female
  • Humans
  • Intrauterine Devices / adverse effects*
  • Pregnancy
  • Uterine Cervical Neoplasms / etiology*
  • Uterine Cervical Neoplasms / pathology
  • Uterine Neoplasms / etiology*
  • Uterine Neoplasms / pathology