Investigation of hirsutism: testosterone is not enough

Ann Clin Biochem. 1983 Sep:20 (Pt 5):262-3. doi: 10.1177/000456328302000502.

Abstract

In a consecutive series of 41 hirsute women clinically classified as benign androgen excess, only 34% were found to have elevated plasma 'total' testosterone (T), 22% having subnormal sex hormone binding globulin (SHBG). When expressed as the ratio T/SHBG ('free androgen index'), 85% of the patients had values above the normal range. It is concluded that this index is more reliable than total testosterone in assessing androgen status in female patients.

MeSH terms

  • Adult
  • Androgens / blood
  • Female
  • Hirsutism / blood*
  • Humans
  • Middle Aged
  • Protein Binding
  • Sex Hormone-Binding Globulin / metabolism*
  • Testosterone / blood*

Substances

  • Androgens
  • Sex Hormone-Binding Globulin
  • Testosterone