Toxicity of the Alternaria metabolites alternariol, alternariol methyl ether, altenuene, and tenuazonic acid in the chicken embryo assay

Appl Environ Microbiol. 1983 Dec;46(6):1420-2. doi: 10.1128/aem.46.6.1420-1422.1983.

Abstract

The effects in the chicken embryo assay of four Alternaria metabolites (alternariol [AOH], alternariol methyl ether [AME], altenuene [ALT], and tenuazonic acid [TA]) were investigated. Administered to 7-day-old chicken embryos by yolk sac injection, AOH, AME, and ALT caused no mortality or teratogenic effect at doses up to 1,000, 500, and 1,000 micrograms per egg, respectively. TA exhibited a calculated 50% lethal dose of 548 micrograms per egg, with no teratogenic effect observed at either lethal or sublethal doses.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alternaria / metabolism*
  • Animals
  • Antibiotics, Antineoplastic / toxicity*
  • Chick Embryo
  • Food Contamination
  • Lactones / toxicity*
  • Lethal Dose 50
  • Mitosporic Fungi / metabolism*
  • Tenuazonic Acid / toxicity*

Substances

  • Antibiotics, Antineoplastic
  • Lactones
  • altenuene
  • Tenuazonic Acid
  • alternariol
  • alternariol monomethyl ether