Effects of 1 alpha-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3, 1,24,25-trihydroxyvitamin D3, and 1,25,26-trihydroxyvitamin D3 on mineral metabolism and 1,25-dihydroxyvitamin D concentrations in dairy cows

J Dairy Sci. 1983 Jan;66(1):59-66. doi: 10.3168/jds.S0022-0302(83)81753-6.

Abstract

Six mature, nonlactating, nonpregnant Jersey cows were treated with five 1-alpha-hydroxylated metabolites of vitamin D3 to compare relative potencies of the metabolites. Blood plasma 1,25-dihydroxyvitamin D peaked at about 1000 pg/ml 12 h after intramuscular injection of 500 micrograms 1,25-dihydroxyvitamin D3 but returned to preinjection concentration within 3 to 4 days. Administration of 500 micrograms 1-alpha-hydroxyvitamin D3 intramuscularly led to a gradual increase in 1,25-dihydroxyvitamin D concentration to 500 pg/ml 48 h after treatment. When 500 micrograms of 1,25-dihydroxyvitamin D3 or 1 alpha-hydroxyvitamin D3 were given orally, plasma 1,25-dihydroxyvitamin D peaked at about 200 and 100 pg/ml, respectively. The decline from peak concentrations occurred more slowly after oral treatment than after intramuscular treatment. Plasma calcium was increased by 20 to 30% for a week or more, depending on 1,25-dihydroxyvitamin D concentrations in plasma. All treatments resulted in calciuria. Treatment with 1 or 3 mg doses of 1,24(R),25-trihydroxyvitamin D3 or both carbon-25 stereoisomers of 1,25,26-trihydroxyvitamin D3 induced smaller and less protracted changes in plasma minerals.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Animals
  • Calcitriol / pharmacology*
  • Calcium / metabolism
  • Cattle / metabolism*
  • Dihydroxycholecalciferols / blood
  • Female
  • Hydroxycholecalciferols / pharmacology*
  • Injections, Intramuscular / veterinary
  • Magnesium / metabolism
  • Minerals / metabolism*
  • Vitamin D / metabolism*

Substances

  • Dihydroxycholecalciferols
  • Hydroxycholecalciferols
  • Minerals
  • Vitamin D
  • 1,24,25-trihydroxyvitamin D3
  • 1,25,26-trihydroxyvitamin D3
  • Calcitriol
  • Magnesium
  • Calcium