Sulfoxide reductase activity of liver aldehyde oxidase

Biochim Biophys Acta. 1983 Sep 14;747(1-2):86-92. doi: 10.1016/0167-4838(83)90125-5.

Abstract

The present study provides evidence that guinea pig and rabbit liver aldehyde oxidase (EC 1.2.3.1) in the presence of its electron donors such as aldehydes or N-heterocyclic compounds functions as a sulfoxide reductase towards sulindac and other sulfoxide compounds. In addition, the study shows that a combination of liver aldehyde oxidase and milk xanthine oxidase also exhibits sulfoxide reductase activity in the presence of xanthine, and electron donor of xanthine oxidase. Based on these facts, we propose a new electron-transfer system consisting of these two flavoenzymes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehyde Oxidase
  • Aldehyde Oxidoreductases / isolation & purification
  • Aldehyde Oxidoreductases / metabolism*
  • Animals
  • Cattle
  • Female
  • Guinea Pigs
  • Kinetics
  • Liver / enzymology*
  • Milk / enzymology
  • Oxidation-Reduction
  • Oxidoreductases / isolation & purification
  • Oxidoreductases / metabolism*
  • Oxidoreductases Acting on Sulfur Group Donors
  • Rabbits
  • Substrate Specificity
  • Xanthine Oxidase / metabolism

Substances

  • Oxidoreductases
  • Xanthine Oxidase
  • Aldehyde Oxidoreductases
  • Aldehyde Oxidase
  • Oxidoreductases Acting on Sulfur Group Donors
  • sulfoxide reductase