LAGRAN program for area and moments in pharmacokinetic analysis

Comput Programs Biomed. 1983 Jun;16(3):203-16. doi: 10.1016/0010-468x(83)90082-x.


A computer program is described for examination of areas (AUC) and moments of serum concentration vs time data using the Lagrange technique alone or in conjunction with linear or log-trapezoidal methods. The suitability of the Lagrange polynomial approximations to the experimental data during AUC computation is possible through output of interpolated values between consecutive data points. Ill-fitting AUC's between any data points can be replaced with values generated by either trapezoidal method. Along with the partial and total AUC and moment, the program generates model-independent pharmacokinetic parameters such as plasma clearance, terminal slope, half-life, volume of distribution at steady-state, mean residence time, and variance of the residence time.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Computers*
  • Kinetics
  • Pharmaceutical Preparations / blood
  • Pharmaceutical Preparations / metabolism*
  • Prednisolone / metabolism
  • Rabbits
  • Software*


  • Pharmaceutical Preparations
  • Prednisolone