Complete nucleotide sequence of the nucleoprotein gene of influenza B virus

J Virol. 1983 Sep;47(3):642-8. doi: 10.1128/JVI.47.3.642-648.1983.


A DNA copy of influenza B/Singapore/222/79 viral RNA segment 5, containing the gene coding for the nucleoprotein (NP), has been cloned in Escherichia coli plasmid pBR322, and its nucleotide sequence has been determined. The influenza B NP gene contains 1,839 nucleotides and codes for a protein of 560 amino acids with a molecular weight of 61,593. Comparison of the influenza B NP amino acid sequence with that of influenza A NP (A/PR/8/34) reveals 37% direct homology in the aligned regions, indicating a common ancestor. However, influenza B NP has an additional 50 amino acids at its N-terminal end. As is the case with influenza A NP, influenza B NP is a basic protein, with its charged residues relatively evenly distributed rather than clustered. The structural homology suggests functional similarity between the NP of influenza A and B viruses.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cloning, Molecular
  • DNA
  • Genes, Viral*
  • Influenza A virus
  • Molecular Sequence Data
  • Nucleocapsid Proteins
  • Nucleoproteins / genetics*
  • Orthomyxoviridae / genetics*
  • RNA, Messenger
  • RNA, Viral
  • Viral Core Proteins / genetics*
  • Viral Proteins / genetics*


  • Nucleocapsid Proteins
  • Nucleoproteins
  • RNA, Messenger
  • RNA, Viral
  • Viral Core Proteins
  • Viral Proteins
  • nucleoprotein, influenza B virus
  • DNA

Associated data

  • GENBANK/K01139