Psychiatric disorders in the relatives of probands with affective disorders. The Yale University--National Institute of Mental Health Collaborative Study

Arch Gen Psychiatry. 1984 Jan;41(1):13-21. doi: 10.1001/archpsyc.1984.01790120015003.


A family study of psychiatric disorders in 2,003 first-degree relatives of 335 probands found increased rates of bipolar I disorder and major depression (MD) in the relatives of probands with bipolar disorder and increased rates of MD in the relatives of probands with MD. There was a similarity in rates of affective disorders in the relatives of ambulatory and of hospitalized depressed probands (suggesting that ambulatory depressed patients may be as suitable as hospitalized ones for biological studies) and a comparability of rates of illness in relatives between centers for most disorders when comparable diagnostic criteria and procedures were used.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Age Factors
  • Ambulatory Care
  • Bipolar Disorder / diagnosis
  • Bipolar Disorder / genetics*
  • Connecticut
  • Depressive Disorder / diagnosis
  • Depressive Disorder / genetics*
  • Female
  • Hospitalization
  • Humans
  • Male
  • Mental Disorders / diagnosis
  • Mental Disorders / genetics
  • Middle Aged
  • National Institute of Mental Health (U.S.)
  • Psychiatric Status Rating Scales
  • Research Design
  • Risk
  • Sex Factors
  • United States