Capsaicin causes selective damage to type I synaptic glomeruli in rat substantia gelatinosa

Brain Res. 1984 Jan 9;290(2):380-3. doi: 10.1016/0006-8993(84)90961-2.

Abstract

Most type I synaptic glomeruli were lacking in adult rats given capsaicin neonatally, while topical cord applications of the drug caused dense degeneration of numerous CI- and very few CIIa-terminals. These data give support to the presumable origin of CI-terminals from unmyelinated primary afferents and suggest that CIIa-terminals may belong to small myelinated afferents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Capsaicin / toxicity*
  • Microscopy, Electron
  • Rats
  • Spinal Cord / ultrastructure*
  • Substantia Gelatinosa / drug effects
  • Substantia Gelatinosa / ultrastructure*
  • Synapses / drug effects
  • Synapses / ultrastructure*

Substances

  • Capsaicin