Characterization of a murine monoclonal antibody specific for human early lymphohemopoietic cells

Hum Immunol. 1984 Jan;9(1):9-20. doi: 10.1016/0198-8859(84)90003-x.


This paper summarizes the results of the characterization of A10, a murine monoclonal antibody which recognizes an epitope not restricted to cells of a definite lineage, but which seems to be specific for an early differentiation antigen present on precursors of circulating T and B cells. The structure recognized by the A10 monoclonal antibody, although strikingly structurally similar to the HLA-A,B,C complex, is immunologically different both from histocompatibility antigens and from beta 2 microglobulin. Furthermore, the distribution of the A10 antigen is analyzed in different cell and tissue samples, both in health and disease conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology*
  • Antibodies, Neoplasm / immunology*
  • Antibody Specificity
  • Antigens / immunology
  • Antigens, Neoplasm / immunology
  • Cell Differentiation
  • Female
  • Hematopoietic Stem Cells / immunology*
  • Humans
  • Leukemia / immunology*
  • Lymphocytes / immunology*
  • Lymphoma / immunology
  • Mice


  • Antibodies, Monoclonal
  • Antibodies, Neoplasm
  • Antigens
  • Antigens, Neoplasm