The organ uptake of intravenously administered colloidal particles can be altered using a non-ionic surfactant (Poloxamer 338)

FEBS Lett. 1984 Feb 13;167(1):79-82. doi: 10.1016/0014-5793(84)80836-4.


Small polystyrene particles coated with a high Mr non-ionic surfactant (Poloxamer 338) are diverted from the reticuloendothelial system of the liver and spleen to other tissue sites. These results are discussed in terms of the adsorption of the Poloxamer to the particle surface and the implications for drug targeting.

MeSH terms

  • Animals
  • Colloids*
  • Injections, Intravenous
  • Liver / metabolism
  • Mononuclear Phagocyte System / metabolism*
  • Poloxalene / pharmacology*
  • Polyethylene Glycols / pharmacology*
  • Rabbits
  • Spleen / metabolism
  • Tissue Distribution


  • Colloids
  • Polyethylene Glycols
  • Poloxalene