Prevalence of achlorhydria in a normal population and its relation to serum gastrin

Hepatogastroenterology. 1984 Feb;31(1):41-3.

Abstract

In a middle-aged group of normal subjects achlorhydria after maximal stimulation with pentagastrin was found in 12 out of 366 males (3%) and 2 out of 198 females (1%); 13 of these 14 (93%) had an elevated serum gastrin, of which nine were more than two times normal. In another 11 persons a moderately elevated serum gastrin - less than two times normal - was found in absence of achlorhydria. At least seven of them had hypochlorhydria. Of 540 persons with a normal serum gastrin one had achlorhydria. Determination of the serum gastrin appeared to be fairly reliable as a method of detecting achlorhydria.

MeSH terms

  • Achlorhydria / blood*
  • Adult
  • Alcian Blue / blood*
  • Fasting
  • Female
  • Gastric Acid / metabolism
  • Gastric Acidity Determination
  • Gastric Juice / analysis
  • Humans
  • Hydrogen-Ion Concentration
  • Indoles / blood*
  • Male
  • Middle Aged
  • Pentagastrin
  • Phenazines / blood*
  • Phenothiazines / blood*
  • Resorcinols / blood*

Substances

  • Indoles
  • Phenazines
  • Phenothiazines
  • Resorcinols
  • astrin
  • Pentagastrin
  • Alcian Blue