Tc-99m-galactosyl-neoglycoalbumin: in vivo characterization of receptor-mediated binding to hepatocytes

Radiology. 1984 Apr;151(1):191-6. doi: 10.1148/radiology.151.1.6701314.


The biodistribution and kinetics of a receptor-binding hepatic radiopharmaceutical, Tc-99m-galactosyl-neoglycoalbumin (Tc-NGA), were investigated using mammalian and avian models. The radiopharmaceutical exhibited four significant features associated with receptor-mediated binding at the hepatocyte membrane in mammals: (a) high tissue specificity, (b) high molecular specificity, (c) affinity-dependent uptake, and (d) dose-dependent uptake. Diminished hepatic uptake by the avian model illustrated low nonspecific binding. The kinetic sensitivity to ligand-receptor affinity and stoichiometry illustrated the principal feature of receptor-binding radio-pharmaceuticals, namely, quantitative assessment of tissue function based upon the biochemical interaction of a ligand and its specific receptor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Albumins / administration & dosage
  • Albumins / metabolism*
  • Animals
  • Asialoglycoprotein Receptor*
  • Carrier Proteins / metabolism
  • Cell Membrane / metabolism
  • Chickens
  • Dose-Response Relationship, Drug
  • Kinetics
  • Liver / diagnostic imaging
  • Liver / metabolism*
  • Organotechnetium Compounds*
  • Rabbits
  • Radionuclide Imaging
  • Receptors, Drug / metabolism*
  • Technetium / administration & dosage
  • Technetium / metabolism*
  • Tissue Distribution


  • Albumins
  • Asialoglycoprotein Receptor
  • Carrier Proteins
  • Organotechnetium Compounds
  • Receptors, Drug
  • hepatic sialoglycoprotein receptor
  • technetium Tc 99m neogalactoalbumin
  • Technetium