Social and environmental influences on blood serotonin concentrations in monkeys

Arch Gen Psychiatry. 1984 Apr;41(4):405-10. doi: 10.1001/archpsyc.1984.01790150095013.


Dominant male adult vervet monkeys have whole-blood serotonin concentrations approximately twice those of subordinate adult males. We examined the effects of spontaneous and induced changes in social status, temporary isolation from the social group, and membership in single male groups on whole-blood serotonin concentrations. We found that in male vervet monkeys, elevated blood serotonin concentration is a state-dependent consequence of active occupation of the dominant male social position, and we believe that a reinterpretation of the significance of hyperserotonemia in humans may be warranted.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cercopithecus / blood*
  • Chlorocebus aethiops / blood*
  • Depressive Disorder / blood
  • Dominance-Subordination*
  • Humans
  • Male
  • Models, Biological
  • Serotonin / blood*
  • Social Behavior
  • Social Dominance*
  • Social Environment*
  • Social Isolation


  • Serotonin