Phosphatidylethanol formation in rat organs after ethanol treatment

Biochim Biophys Acta. 1984 Mar 27;793(1):119-22. doi: 10.1016/0005-2760(84)90060-2.


An abnormal acidic phospholipid was found in high concentration in kidney and brain, and also in other organs of rats exposed to ethanol by i.p. injection or by a liquid diet. The compound could be identified as phosphatidylethanol. Phosphatidylethanol is probably formed in cell membranes by a phospholipase D-catalyzed transphosphatidylation reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / metabolism
  • Ethanol / pharmacology*
  • Kidney / metabolism
  • Liver / metabolism
  • Myocardium / metabolism
  • Phospholipids / biosynthesis*
  • Phospholipids / metabolism*
  • Rats
  • Tissue Distribution


  • Phospholipids
  • Ethanol