Renal side effect of nifedipine

Clin Cardiol. 1984 Jan;7(1):29-30. doi: 10.1002/clc.4960070107.


The possibility of a renal-related side effect from nifedipine has been investigated by comparing the effects on plasma creatinine level of coronary arteriography in two groups of patients: one group treated with nifedipine and the other treated with various drugs but without calcium inhibitor. Results showed a moderate (mean, 13%) but highly significant rise in the 27 patients receiving various drugs but no calcium inhibitor. Plasma creatinine change was not significant (mean, 3%) in the 26 patients treated with nifedipine. In the conditions of this study, this difference could only be related to nifedipine treatment. In conclusion, nifedipine may have exerted a protective effect against radiocontrast media nephrotoxicity, which deserves further investigation.

MeSH terms

  • Acute Kidney Injury / chemically induced
  • Acute Kidney Injury / prevention & control*
  • Contrast Media / adverse effects
  • Coronary Angiography
  • Creatinine / blood
  • Humans
  • Male
  • Middle Aged
  • Nifedipine / pharmacology*


  • Contrast Media
  • Creatinine
  • Nifedipine