Visual results following cobalt plaque radiotherapy for posterior uveal melanomas

Ophthalmology. 1984 Feb;91(2):131-6. doi: 10.1016/s0161-6420(84)34317-2.


Visual results of cobalt plaque radiotherapy on the eyes of 77 patients with posterior uveal melanoma in one eye and pretreatment visual acuity of 20/25 or better in both eyes were analyzed using actuarial methods. The study demonstrated that eyes receiving a radiation dose in excess of 5,000 rad to the fovea and/or optic disc commonly lose a substantial amount of vision within 2 to 3 years. It also showed that eyes treated by cobalt plaque radiotherapy for a large posterior uveal melanoma are more likely to suffer profound visual loss than those treated for a medium or small melanoma. The predominant cause of severe visual loss in these patients appeared to be foveal radiation retinopathy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Choroid
  • Cobalt / therapeutic use
  • Female
  • Humans
  • Male
  • Melanoma / radiotherapy
  • Middle Aged
  • Radiotherapy / adverse effects*
  • Retinal Diseases / etiology
  • Uveal Neoplasms / radiotherapy
  • Vision Disorders / etiology*
  • Visual Acuity


  • Cobalt