Caffeine reduces amphetamine-induced activity in asymmetrical interaction

Pharmacol Biochem Behav. 1984 Mar;20(3):387-9. doi: 10.1016/0091-3057(84)90276-4.


Caffeine-amphetamine interactions were studied to determine whether attenuation of amphetamine-induced activity by caffeine pretreatment (30 mg/kg) is the result of increased or decreased sensitivity to amphetamine. Caffeine pretreatment attenuated amphetamine activity in the rats without producing a horizontal shift in the dose-response curve. Results support a reduction in sensitivity to amphetamine. A cross-tolerance design revealed an asymmetrical interaction between caffeine and amphetamine. Multiple caffeine treatments (30 mg/kg) produced tolerance and attenuation of subsequent amphetamine activity (1.5 mg/kg). Amphetamine did not produce tolerance or affect subsequent caffeine-induced activity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amphetamine / antagonists & inhibitors*
  • Animals
  • Caffeine / pharmacology*
  • Dose-Response Relationship, Drug
  • Drug Tolerance
  • Male
  • Motor Activity / drug effects*
  • Rats


  • Caffeine
  • Amphetamine