Gas-liquid chromatographic determination of total phenylacetic acid in urine

Anal Biochem. 1984 Jan;136(1):202-7. doi: 10.1016/0003-2697(84)90326-9.


A gas-liquid chromatographic procedure to measure total phenylacetic acid in urine is described. The method is simple, rapid, and reliable. Normal subjects (N = 48) excreted 141.1 +/- 10.1 mg/24 h. Untreated depressed patients (N = 42) excreted 102.77 +/- 15.9 mg/24 h. The difference in the means is significant and supports the role of phenylacetic acid as a biological marker in certain kinds of mental illnesses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, Gas / methods
  • Depressive Disorder / urine
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Hydrolysis
  • Phenylacetates / urine*


  • Phenylacetates
  • phenylacetic acid