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, 218 (2), 371-7

Effect of Thioacetamide on Cytochrome P-450 Synthesis in Rat Liver

Effect of Thioacetamide on Cytochrome P-450 Synthesis in Rat Liver

S Satyabhama et al. Biochem J.

Abstract

A single injection of thioacetamide to rats results in a striking decrease in liver cytochrome P-450. The drug blocks the phenobarbitone-mediated induction of cytochrome P-450b. Under these conditions, there is a decrease in the synthesis of cytochrome P-450b, which is essentially due to a decrease in the amount of translatable mRNA for cytochrome P-450b. This effect of thioacetamide is not due to a general effect on protein synthesis or polyribosome stability. Multiple injections of thioacetamide also decrease the synthesis of cytochrome P-450b and the amounts of its translatable mRNA.

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References

    1. J Biol Chem. 1964 Jul;239:2379-85 - PubMed
    1. Cancer Res. 1978 Jul;38(7):2043-7 - PubMed
    1. Lab Invest. 1963 Oct;12:955-60 - PubMed
    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. Arch Biochem Biophys. 1979 Feb;192(2):524-32 - PubMed

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