Phagocyte-induced mutation in Chinese hamster ovary cells

Cancer Lett. 1984 Apr;22(3):337-41. doi: 10.1016/0304-3835(84)90172-1.

Abstract

Human phagocytic cells elaborate toxic oxygen metabolites which can cause mutations in bacteria and sister chromatid exchanges in cultured mammalian cells. In the present study we demonstrate that human phagocytes can induce mutations in Chinese hamster ovary cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Cricetinae
  • Cricetulus
  • Female
  • Humans
  • Hypoxanthine Phosphoribosyltransferase / genetics
  • Methods
  • Mutation*
  • Ovary
  • Phagocytes / physiology*
  • Sister Chromatid Exchange

Substances

  • Hypoxanthine Phosphoribosyltransferase