Characterization of the butyl homologues of delta1-tetrahydrocannabinol, cannabinol and cannabidiol in samples of cannabis by combined gas chromatography and mass spectrometry

J Pharm Pharmacol. 1976 Apr;28(4):280-5. doi: 10.1111/j.2042-7158.1976.tb04153.x.


The butyl homologues of delta1-tetrahydrocannabinol, delta1-tetrahydrocannabinolic acid, cannabinol and cannabidiol have been identified in several samples of cannabis. 8 samples contained delta1-tetrahydrocannabinolic acid, one sample contained cannabinol and one sample contained both cannabinol and cannabidiol. Separation by gas chromatography and identification by gas chromotography-mass spectrometry was achieved by the preparation of trimethylsilyl, d9-trimethylsilyl, triethylsilyl and tri-n-propylsilyl derivatives.

MeSH terms

  • Cannabidiol / analogs & derivatives
  • Cannabidiol / analysis*
  • Cannabis / analysis*
  • Chromatography, Gas
  • Decarboxylation
  • Dronabinol / analogs & derivatives
  • Dronabinol / analysis*
  • Mass Spectrometry


  • Cannabidiol
  • Dronabinol