Stability of cefsulodin in aqueous buffered solutions and some intravenous admixtures

J Clin Hosp Pharm. 1984 Mar;9(1):21-7. doi: 10.1111/j.1365-2710.1984.tb00915.x.

Abstract

The stability of cefsulodin in aqueous solutions of various pH values, buffer concentrations, ionic strengths and intravenous admixtures were studied using a stability-indicating high-pressure liquid chromatography method. The pH range of optimum stability was determined to be 3.2-5.7. Cefsulodin was more stable on the acidic and less on the alkaline side as compared with most of the other cephalosporins such as cefoxitin (pH range of optimum stability approximately 4-7). In 5% dextrose and 0.9% sodium chloride injection, cefsulodin was stable (at least 90% potent) for about 1, 17 and at least 60 days at 24 degrees, 5 degrees and -10 degrees C, respectively.

MeSH terms

  • Buffers
  • Cefsulodin
  • Cephalosporins / analysis*
  • Chemical Phenomena
  • Chemistry
  • Chromatography, High Pressure Liquid / methods
  • Drug Stability
  • Drug Storage
  • Hydrogen-Ion Concentration
  • Injections, Intravenous
  • Osmolar Concentration
  • Solutions
  • Temperature
  • Time Factors

Substances

  • Buffers
  • Cephalosporins
  • Solutions
  • Cefsulodin