Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats

Nature. 1984 Apr 19-25;308(5961):705-9. doi: 10.1038/308705a0.

Abstract

In rats with hereditary hypothalamic diabetes insipidus (Brattleboro rats) the gene for the vasopressin precursor lacks a single G residue in the protein-coding region. The mutation gives rise to an open reading frame predicting a hormone precursor having a different C-terminus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Deletion*
  • Diabetes Insipidus / genetics*
  • Genes*
  • Hypothalamus / metabolism
  • Liver / metabolism
  • Mutation
  • Nucleic Acid Hybridization
  • Protein Biosynthesis
  • RNA, Messenger / genetics
  • Rabbits
  • Rats
  • Rats, Brattleboro / genetics*
  • Rats, Mutant Strains / genetics*
  • Reticulocytes / metabolism
  • Vasopressins / genetics*

Substances

  • RNA, Messenger
  • Vasopressins

Associated data

  • GENBANK/L00106
  • GENBANK/L00107
  • GENBANK/V01275
  • GENBANK/V01276
  • GENBANK/X00510
  • GENBANK/X01637