Kimura's disease: a clinico-pathological study of 21 cases and its distinction from angiolymphoid hyperplasia with eosinophilia

Pathology. 1984 Jan;16(1):39-44. doi: 10.3109/00313028409067909.


Kimura's disease is a chronic inflammatory condition producing subcutaneous tumour-like nodules chiefly in the head and neck region. It is characterized histologically by lymphoid follicles, intense aggregations of eosinophils, vascular proliferation and fibrosis. Superficial lymph nodes and parotid glands are sometimes involved. The lesions may persist unchanged for years and new ones are apt to occur. Recurrences are also common. There are no systemic manifestations apart from peripheral blood eosinophilia. The lesion has been recognised as a distinct clinicopathological entity in the Far East for over 40 years. We describe 21 cases of Kimura's disease and discuss its relationship to angiolymphoid hyperplasia with eosinophilia. Although the pathogenesis and etiology of both these lesions are unknown we believe that there are sufficient significant clinical and pathological differences to justify their separation.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Biopsy
  • Child
  • Diagnosis, Differential
  • Eosinophilia / complications*
  • Eosinophilic Granuloma / diagnosis*
  • Eosinophilic Granuloma / pathology
  • Female
  • Humans
  • Hyperplasia
  • Lymph Nodes / pathology*
  • Male
  • Middle Aged
  • Mikulicz' Disease / diagnosis*
  • Mikulicz' Disease / pathology
  • Parotid Gland / pathology*