The role of maximal oxygen uptake in exercise performance

Clin Chest Med. 1984 Mar;5(1):51-62.


The maximal ability to deliver oxygen to the tissues of the body establishes the upper limit of endurance performance; however, the ability of the skeletal muscles to utilize a high oxygen load for a sustained period of time is also of great importance. The fatigue that limits endurance is due to a local limitation of oxygen or substrate, which leads to excessive anaerobic metabolism or decreased energy production. The peripheral adaptation from specific and intense training may further improve endurance performance.

MeSH terms

  • Aerobiosis
  • Aging
  • Anaerobiosis
  • Body Composition
  • Cardiac Output
  • Energy Metabolism
  • Female
  • Heart / physiology
  • Heart Rate
  • Humans
  • Male
  • Muscle Contraction
  • Muscles / blood supply
  • Muscles / metabolism
  • Oxygen / physiology
  • Oxygen Consumption*
  • Physical Exertion*
  • Physical Fitness
  • Regional Blood Flow
  • Respiration*
  • Vascular Resistance


  • Oxygen