Penicillin concentrations in blood and spinal fluid after a single intramuscular injection of penicillin G benzathine

Eur J Clin Microbiol. 1984 Apr;3(2):147-9. doi: 10.1007/BF02014334.

Abstract

The concentration of penicillin in cerebrospinal fluid and blood was measured after a single i.m. injection of 1.44 g penicillin G benzathine in 18 individuals (4 with neurosyphilis and 14 with neurological symptoms but not syphilis). Only one person had a treponemicidal concentration in the cerebrospinal fluid.

MeSH terms

  • Adult
  • Aged
  • Female
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Neurosyphilis / drug therapy
  • Penicillin G Benzathine / administration & dosage
  • Penicillin G Benzathine / metabolism*
  • Penicillins / blood
  • Penicillins / cerebrospinal fluid
  • Treponema / drug effects

Substances

  • Penicillins
  • Penicillin G Benzathine