Naloxone antagonism of stress-induced augmentation of frontal cortex dopamine metabolism

Eur J Pharmacol. 1984 Mar 2;98(3-4):437-9. doi: 10.1016/0014-2999(84)90295-4.


Foot shock stress selectively elevates dopamine metabolism in the medial frontal cortex but not nucleus accumbens or caudate nucleus. Pretreatment with a low dose of naloxone, an opiate antagonist, reversed the elevation in medial frontal cortex dopamine metabolism observed after foot shock. These data support the hypothesis that the stress-induced release of endogenous opioids cause an excitation of mesocortical dopamine neurons.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Depression, Chemical
  • Dopamine / metabolism*
  • Electroshock
  • Frontal Lobe / metabolism*
  • Male
  • Naloxone / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Stress, Physiological / metabolism*


  • Naloxone
  • Dopamine